Health Effects Assessment Summary (HEAST) for
Nitrobenzene
CAS: 000098-95-3
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
| ||||||
| Alternative Methods | ||||||
| ||||||
| Carcinogenicity | ||||||
|
| Subchronic [RfD]: (see comment) |
5E-3 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Blood / Hematological effects | |||
| Adrenal / Lesions | ||||
| Kidney / Lesions | ||||
| Liver / Lesions | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Mouse, Rat | LOAEL | 25 mg/cu m | 90 days | |
| References | ||||
| 1984 | CIIT (Chemical Industry Institute of Toxicology). 1984. Ninety-day inhalation study of Nitrobenzene in F-344 rats, cd rats and B6C3F1 mice with cover letter dated 6/24/84 and EPA response dated 8/06/84, unpublished study. FYI-OTS-0784-0333 and computer print-out of pathology finding. | |||
| 1987 | U.S. EPA. 1987. Health effects assessment for Nitrobenzene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC | |||
| 1985 | U.S. EPA. 1985. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | Based on route to route extrapolation. | |||
| Chronic [RfC]: (see comment) |
2E-3 mg/cu m | |||
| Uncertainty Factor: | 10000 | |||
| Subchronic [RfC]: (see comment) |
2E-2 mg/cu m | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Blood / Hematological effects | |||
| Adrenal / Lesions | ||||
| Kidney / Lesions | ||||
| Liver / Lesions | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Mouse, Rat | LOAEL | 25 mg/cu m | 90 days | |
| References | ||||
| 1984 | CIIT (Chemical Industry Institute of Toxicology). 1984. Ninety-day inhalation study of Nitrobenzene in F-344 rats, CD rats and B6C3F1 mice with cover letter dated 6/24/84 and EPA response dated 8/06/84, Unpublished study, FYI-OTS-0784-0333 and computer print-out of pathology finding. | |||
| 1987 | U.S. EPA. 1987. Health effects assessment for Nitrobenzene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC. | |||
| Subchronic [RfC] Comments: | 6E-3 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). | |||
| Chronic [RfC] Comments: | 6E-4 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). | |||
| General Comments: | The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group. | |||
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