Health Effects Assessment Summary (HEAST) for
Nitrite
CAS: 014797-65-0
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
1E-1 mg/kg/day | |||
| Uncertainty Factor: | 10 | |||
| Route: | Oral: water | |||
| Target Organ / Critical Effect: | Blood / Methemoglobinemia | |||
| Species | Effect Level | Dose | ||
| Human | NOEL | 10 ppm | ||
| References | ||||
| 1951 | Walton G. 1951. Survey of literature relating to infant methemoglobinemia due to Nitrate-contaminated water. Am J Pub Health. 41: 986-996. | |||
| 1989 | U.S. EPA. 1989. Health and environmental effects document for Nitrite. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| 1992 | U.S. EPA. 1992. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | This value is based on nitrate (nitrogen) data from the most sensitive human population (infants). The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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