Health Effects Assessment Summary (HEAST) for
Nickel, Soluble Salts
CAS: VARIOUS
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
2E-2 mg/kg/day | |||
| Uncertainty Factor: | 300 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Whole body / Decreased weight | |||
| Organs, major / Decreased weight | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 100 ppm | 2 years | |
| References | ||||
| 1976 | Ambrose A.M., D.S. Larson, J.R. Borzelleca and G.R. Hennigar, Jr. 1976. Long-term toxicologic assessment of Nickel in rats and dogs. J Good Sci Technol. 13: 181-187. | |||
| 1991 | U.S. EPA. 1991. Drinking water quantification of toxicologic effects for Nickel. Prepared by the Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Cincinnati, OH for the Office of Water, Washington, DC | |||
| 1991 | U.S. EPA. 1991. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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