Health Effects Assessment Summary (HEAST) for
Monochloramine
CAS: 010599-90-3
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
1E-1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: drinking water | |||
| Target Organ / Critical Effect: | Whole body / Weight changes | |||
| Liver / Weight changes | ||||
| Kidney / Weight changes | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 9.5 mg/kg/day | 2 years | |
| References | ||||
| 1990 | NTP (National Toxicology Program). 1990. NTP technical report on the toxicology and carcinogenesis studies of Chlorinated and Chloraminated water in F344/N rats and B6C3F1 mice (drinking water studies). NTP TR 392, National Institutes of Health. | |||
| 1992 | U.S. EPA. 1992. Drinking water criteria document for Chloramines. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Health and Ecological Criteria Division, Office of Science and Technology, Office of Water, Washington, DC | |||
| 1992 | U.S. EPA. 1992. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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