|
|
|
|
Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
|
Subchronic [RfD]: (see comment) |
5E-3 mg/kg/day |
|
Uncertainty Factor: |
30 |
|
Route: |
Oral: water, diet |
|
Target Organ / Critical Effect: |
Urine / Increased uric acid |
|
Joints / Pain, swelling |
|
Blood / Decreased copper levels |
|
Species |
Effect Level |
Dose |
|
Human |
LOAEL |
0.14 mg/kg/day |
|
|
References |
1961 | Kolval'skiy V.V., G.A. Yarovaya and D.M. Shmavonyan. 1961. Changes of purine metabolism in man and animals under conditions of Molybdenum biogeochemical provinces. Zh Obshch Biol. 22: 179-191. (in Russian, translation) |
1991 | U.S. EPA. 1991. RfD/RfC Work Group. |
|
Subchronic [RfD] Comments: |
The chronic oral RfD was adopted as the subchronic oral [RfD]. |
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