HEAST Summary

Health Effects Assessment Summary (HEAST) for
Mirex

CAS: 002385-85-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Notes/Comments: on-Line

Carcinogenicity

EPA Group: on-Line

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: (see comment)	2E-4 mg/kg/day

Uncertainty Factor:	300

Route:	Oral: diet

Target Organ / Critical Effect:	Liver / Cytomegaly
	Liver / Fatty metamorphosis
	Liver / Angiectasis
	Thyroid / Cystic follicles

Species	Effect Level	Dose	Experiment Length
Rat	NOAEL	0.07 mg/kg/day	2 years

References
1990	NTP (National Toxicology Program). 1990. Toxicology and carcinogenesis studies of Mirex (CAS No. 2385-85-5) in F344/N rats. (feed studies). NTP TR. 313.
1992	U.S. EPA. 1992. RfD/RfC Work Group.

Subchronic [RfD] Comments:	The chronic oral RfD was adopted as the subchronic oral [RfD].


Carcinogenicity

Route:	Oral: diet

Target Organ / Cancer:	Liver / Adenoma
	Liver / Carcinoma

Species	Experiment Length	EPA Group
Rat	2 years	B2

References
1990	NTP (National Toxicology Program). 1990. NTP technical report on the toxicology and carcinogenesis studies of Mirex (CAS No. 2385-85-5) in F344/N rats. (feed studies). NTP TR 313. U.S. Dept of Health and Human Services. Public Health Service. National Institutes of Health.
1993	U.S. EPA. 1993. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

EPA Group Comment:	Under review, classification subject to change.

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