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Health Effects Assessment Summary (HEAST) for

Metolachlor

CAS: 051218-45-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: 1.5E-1 mg/kg/day
Uncertainty Factor: 100

Subchronic [RfD]:
(see comment)		 1.5E-1 mg/kg/day

Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: Whole body / Decreased weight gain

Species Effect Level Dose Experiment Length
Rat NOAEL 300 ppm 2 years

References
1983 Tisdel M., T. Jackson, P. MacWilliams et al. 1983. Two-year chronic oral toxicity and oncogenicity study with Metolachlor in albino rats: Study No. 80030. Final report. (unpublished study received May 24, 1983 under 100-587. Prepared by Hazleton Raltech, Inc., Submitted by Ciba-Geigy Corp., Greensboro, NC: CDL:250369-A, 250370, 250371, 250272, 259373, 259374, 259375.) Referred to as Ciba-Geigy, 1983 in U.S. EPA (1993). MRID 00129377. Available from EPA, write to FOI, EPA, Washington, DC 20460.
1981 Smith S.H., C.K. O'Loughlin, C.M. Salamon et al. 1981. Two-generation reproduction study in albino rats with Metolachlor Technical: Study No. 450-0272. Final report. (unpublished study received September 30, 1981 under 100-597. Prepared by Whittaker Corp., Submitted by Ciba-Geigy Corp., Greensboro, NC CDL:245959-a, 245960, 245961.) Referred to as Ciba-Geigy (1981) in U.S. EPA (1993). MRID 00080897. Available from EPA, write to FOI, EPA, Washington, DC 20460.
1993 U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for Metolachlor. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


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