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Health Effects Assessment Summary (HEAST) for

Methylmercury

CAS: 022967-92-6

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 1.5E+0 mg/kg/day

Uncertainty Factor: 10

Route: Oral

Target Organ / Critical Effect: Neurological / Developmental abnormalities

Species Effect Level Dose
Human infants Critial Oral Dose 0.001 mg/kg/day

References
1987 Marsh D.D., T.W. Clarkson, C. Cox et al. 1987. Fetal Methylmercury poisoning: Relationship between concentration in single strands of maternal hair and child effects. Arch Neurol. 44:1017-1022.
1991 Seafood Safety. 1991. Committee on Evaluation of the Safety of Fishery Products. Chapter on Methylmercury. FDA Risk Assessment and Current Regulations. National Academy Press. Washington, DC P. 196-221.
1980 U.S. EPA. 1980. Ambient Water Quality Criteria document for Mercury. Environmental Criteria and Assessment Office, Cincinnati, OH. Office of Water Regulations and Standards, Washington, DC EPA 440/5-80/058. NTIS PB 81-117699.
1995 U.S. EPA. 1995. Mercury study report to congress. Office of Research and Development. Washington, DC. External review draft. EPA/600/P-94/002AB.
1994 U.S. EPA. 1994. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


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