Health Effects Assessment Summary (HEAST) for
Methylenediphenyl Isocyanate, 4,4- / (Diphenylmethane Diisocyanate)
CAS: 000101-68-8
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfC]: (see comment) |
2E-5 mg/cu m | |||
| Uncertainty Factor: | 300 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Nasal cavity / Lesions | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 0.2 mg/cu m | 24 months | |
| References | ||||
| 1990 | Reuzel P.G.J., J.H.G. Arts, M.H.M. Kuypers, et al. 1990. Chronic toxicity/carcinogenicity inhalation study of Polymeric Methylenediphenyl Diisocyanate aerosol in rats. Final report. Prepared by CIVO Institute for the International Isocyanate Institute. | |||
| 1998 | Reuzel P.G.J., J.H.G. Arts,L.G. Lomax, et al. 1998. Chronic inhalation and carcinogenicity study of respirable Polymeric Methylene Diphenyl Diisocyanate (Polymeric MDI) aerosol in rats. Fund Appl Toxicol. 22: 195-210. | |||
| 1993 | U.S. EPA. 1993. RfD/RfC Work Group. | |||
| Subchronic [RfC] Comments: | The chronic inhalation RfC on IRIS was adopted as the subchronic inhalation [RfC]. | |||
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