EPA Home PageSuperfund Risk Assessment Home Page


Health Effects Assessment Summary (HEAST) for

Methylene Chloride / (Dichloromethane)

CAS: 000075-09-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]: 3E+0 mg/cu m
Uncertainty Factor: 100

Subchronic [RfC]: 3E+0 mg/cu m
Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Liver / Toxicity

Species Effect Level Dose Experiment Length
Rat NOAEL 694.8 mg/cu m 2 years

References
1988 Nitschke K.D., J.D. Burek, T.J. Bell, R.J. Kociba, L.W. Rampey and M.J. McKenna. 1988. Methylene Chloride: A 2-year inhalation toxicity and oncogenicity study in rats. Fund Appl Toxicol. 10: 1-12.
1989 U.S. EPA. 1989. Updated health effects assessment for Methylene Chloride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC




Subchronic [RfD]:
(see comment)		 6E-2 mg/kg/day

Uncertainty Factor: 100

Route: Oral: drinking water

Target Organ / Critical Effect: Liver / Toxicity

Species Effect Level Dose Experiment Length
Rat NOAEL 5.85 mg/kg/day 24 months

References
1982 National Coffee Association. 1982. 24-month chronic toxicity and oncogenicity study of Methylene Chloride in rats final report. Prepared by Hazleton Laboratories America, Inc., Vienna, VA. Unpublished
1985 U.S. EPA. 1985. Drinking water criteria document for Methylene Chloride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC
1985 U.S. EPA. 1985. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


[ Risk Assessment Home ]
[ EPA Home | OSWER Home | Superfund Home ]
[ Search EPA | Search Superfund | Whats New | Contact Us ]
Horizontal Rule
URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov
Horizontal Rule