Health Effects Assessment Summary (HEAST) for
Methylene Bromide
CAS: 000074-95-3
| Summary of HEAST Information on-Line | ||||||
| Alternative Methods | ||||||
|
| Chronic [RfD]: (see comment) |
1E-2 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Subchronic [RfD]: (see comment) |
1E-1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Blood / Increased carboxyhemoglobin | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 11 mg/kg/day | 90 days | |
| References | ||||
| 1982 | Keyes D.G., J.W. Henck, G.C. Jersey, R.J. Kociba, D.J. Schwetz and T.D. Landry. 1982. Methylene Bromide: a 90-day repeated inhalation toxicity study in rats and dogs with a subsequent two-year holding period for rats. Toxicology Research Lab, Health and Environmental Sciences, Dow Chemical Co., Midland, MI. | |||
| 1987 | U.S. EPA. 1987. Health and environmental effects profile for Methylene Bromide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| Subchronic [RfD] Comments: | Based on route to route extrapolation, including an absorption factor of 0.5. | |||
| Chronic [RfD] Comments: | Based on route to route extrapolation, including an absorption factor of 0.5. | |||
| General Comments: | No pharmacokinetic data were provided to justify route to route extrapolation for the oral [RfD] values. | |||
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