HEAST Summary

Health Effects Assessment Summary (HEAST) for
Methylene-Bis(2-Chloroaniline), 4,4'-

CAS: 000101-14-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: on-Line

Subchronic [RfD]: on-Line

Carcinogenicity

Oral [Slope Factor]: on-Line

Inhalation [Slope Factor]: on-Line

Oral [Unit Risk]: on-Line

Inhalation [Unit Risk]: on-Line

EPA Group: on-Line

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:	7E-4 mg/kg/day
Uncertainty Factor:	10000

Subchronic [RfD]:	7E-4 mg/kg/day
Uncertainty Factor:	10000

Route:	Oral

Target Organ / Critical Effect:	Liver / Effects
	Bladder / Effects

Species	Effect Level	Dose	Experiment Length
Dog	LOAEL	7.3 mg/kg/day	9 years

References
1977	Stula E.F., J.R. Barnes, H. Sherman, C.F. Reinhardy and J.A. Zapp.1977. Urinary bladder tumors in dogs from 4,4'-Methylene-bis(2-chloroaniline) (MOCA). J Environ Pathol Toxicol. 1(1): 31-50.
1990	U.S. EPA. 1990. Health and environmental effects document for 4,4'-Methylene-bis(2-chloroaniline). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington DC


Carcinogenicity

Oral [Slope Factor]:	1.3E-1 (mg/kg/day)^-1

Inhalation [Slope Factor]: (see comment)	1.3E-1 (mg/kg/day)^-1


Oral [Unit Risk]:	3.7E-6 (µg/L)^-1

Inhalation [Unit Risk]:	3.7E-5 (µg/m³)^-1

Route:	Oral: diet

Target Organ / Cancer:	Lung / Tumors

Species	Experiment Length	EPA Group
Rat	2 years	B2

References
1979	Kommineni C., D.H. Groth, I.J. Frockt, R.W. Voelker and R.P. Stanovick. 1979. Determination of the tumorigenic potential of Methylene-bis-ortho-chloroaniline. J Environ Path Toxicol. 2(5): 149-171.
1975	Stula E.F., H. Sherman, J.P. Zapp, Jr. and J.W. Clayton. 1975. Experimental neoplasia in rat from oral administration of 3,3-Dichlorobenzidine, 4,4-Methylene-bis(2-chloroaniline) and 4,4-Methylene-bis(2-methylaniline). Toxicol Appl Pharmacol. 31(1): 159-176.
1990	U.S. EPA. 1990. Health and environmental effects document for 4,4-Methylene-bis(2-chloroaniline). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

Inhalation Slope Comment:	See Appendix A-II: Dose Conversions on HEAST. Based on route to route extrapolation.

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