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Health Effects Assessment Summary (HEAST) for
Methylaniline, 2-
CAS: 000095-53-4
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Summary of HEAST Information on-Line
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| Carcinogenicity |
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Carcinogenicity |
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| Oral [Slope Factor]: |
2.4E-1 (mg/kg/day)-1 |
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| Oral [Unit Risk]: |
6.9E-6 (µg/L)-1 |
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| Route: |
Oral: diet |
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| Target Organ / Cancer: |
Skin / Fibroma |
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| Species |
Experiment Length |
EPA Group |
| Rat |
93 weeks |
B2 |
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| References |
| 1982 | Hecht S.S., A. El-Boyoumy, A. Rivenson and E. Fiala. 1982. Comparative carcinogenicity of o-Toluidine Hydrochloride and o-Nitrotoluene in F-344 rats. Cancer Lett. 16(1): 103-108. |
| 1987 | U.S. EPA. 1987. Health and environmental effects profile for 2-Methylaniline and 2-Methylaniline Hydrochloride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. |
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Toluidines. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. |
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| General Comment: |
The 1984 HEEP called this compound o-Toluidine, the 1987 HEEP called it 2-Methylaniline. |
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