Health Effects Assessment Summary (HEAST) for
Methyl Styrene, Alpha
CAS: 000098-83-9
| Summary of HEAST Information on-Line | ||||||
| Alternative Methods | ||||||
|
| Chronic [RfD]: (see comment) |
7E-2 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Subchronic [RfD]: (see comment) |
7E-1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Liver / Increased weight | |||
| Kidney / Increased weight | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOEL | 970 mg/cu m | 197 days | |
| References | ||||
| 1956 | Wolf M.A., V.K. Rowe, D.D. McCollister, et al. 1956. Toxicological studies of certain alkylated Benzenes and Benzene. Arch Ind Health. 14:387-398. | |||
| 1987 | U.S. EPA. 1987. Health and environmental effects profile for alpha-Methyl Styrene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| Subchronic [RfD] Comments: | Based on route to route extrapolation using an absorption factor of 0.5. | |||
| Chronic [RfD] Comments: | Based on route to route extrapolation using an absorption factor of 0.5. | |||
| General Comments: | No pharmacokinetic data were provided to justify route to route extrapolation for the oral [RfD] values. | |||
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