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Health Effects Assessment Summary (HEAST) for

Methyl Isobutyl Ketone

CAS: 000108-10-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Alternative Methods
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)		 8E-2 mg/kg/day

Uncertainty Factor: 3000

Subchronic [RfD]: 8E-1 mg/kg/day
Uncertainty Factor: 300

Route: Oral: gavage

Target Organ / Critical Effect: Whole body / Lethargy
Liver / Increased relative weight in females
Liver / Increased absolute weight in females
Kidney / Increased relative weight in females
Kidney / Increased absolute weight in females
Kidney / Increased urinary protein levels in females

Species Effect Level Dose Experiment Length
Rat NOAEL 250 mg/(kg-day) 13 weeks

References
1986 Microbiological Associates. 1986. Subchronic toxicity of Methyl Isobutyl Ketone in Sprague-Dawley rats. Performed for Research Triangle Institute, PO Box 12194, Research Triangle Park, NC, 27709. Final report. Study No. 522104.
1993 U.S. EPA. 1993. RfD/RfC Work Group.
Chronic [RfD] Comments: Withdrawn from IRIS (03/01/91), under review, current number subject to change.





Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]:
(see comment)		 8E-2 mg/cu m

Uncertainty Factor: 1000

Subchronic [RfC]:
(see comment)		 8E-1 mg/cu m

Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Liver / Increased weight
Kidney / Effects

Species Effect Level Dose Experiment Length
Rat NOEL 50 ppm 90 days

References
1983 Union Carbide Corp. 1983. Ninety-day inhalation study in rats and mice sponsored by CMA. U.S. EPA/OTS public files 0750507469.
1987 U.S. EPA. 1987. Health effects assessment for Methyl Ethyl Ketone. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
Subchronic [RfC] Comments: 2E-1 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
Chronic [RfC] Comments: 2E-2 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
General Comments: The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group.


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