Health Effects Assessment Summary (HEAST) for
Methyl Ethyl Ketone
CAS: 000078-93-3
| Summary of HEAST Information on-Line | ||||||||||
| Subchronic and Chronic Toxicity | ||||||||||
|
| Subchronic [RfC]: (see comment) |
1E+0 mg/cu m | |||
| Uncertainty Factor: | 3000 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Fetus / Decreased birth weight | |||
| Species | Effect Level | Dose | Experiment Length | |
| Mouse | NOAEL | 1010 ppm | 10 days | |
| References | ||||
| 1991 | Schwetz B.A., T.J. Mast, R.J. Weigel, et al. 1991. Developmental toxicity of inhaled Methyl Ethyl Ketone in mice. Fund Appl Toxicol. 16: 742-748. | |||
| 1989 | Mast T.J., J.A. Dill, J.J. Evanoff, et al. 1989. Inhalation developmental toxicology studies: Teratology study of Methyl Ethyl Ketone in mice. Final report. Prepared by Pacific Northwest Laboratory, Batelle Memorial Institute, for the National Toxicology Program, Washington, DC PNL-6833 UC-408. | |||
| 1991 | U.S. EPA. 1991. RfD/RfC Work Group. | |||
| Subchronic [RfC] Comments: | The chronic inhalation RfC was adopted as the subchronic inhalation [RfC]. | |||
| Subchronic [RfD]: (see comment) |
2E+0 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: drinking water | |||
| Target Organ / Critical Effect: | Fetus / Decreased birth weight | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 1711 mg/kg/day | Multi-generation | |
| References | ||||
| 1975 | Cox G.E. 1975. Toxicity studies in rats with 2-Butanol: Including growth, reproduction, and teratogenic observations. Food and Drug Research Laboratories, Inc. (91 MR R 1673) | |||
| 1992 | U.S. EPA. 1992. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was modified to estimate the subchronic oral [RfD]. | |||
| General Comments: | Multigeneration dvelopment study performed with the surrogate 2-Butanol, a metabolite of Methyl Ethyl Ketone. | |||
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