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Health Effects Assessment Summary (HEAST) for

Methyl Acrylate

CAS: 000096-33-3

Summary of HEAST Information on-Line

Alternative Methods
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)		 3E-2 mg/kg/day

Uncertainty Factor: 100

Subchronic [RfD]:
(see comment)		 3E-2 mg/kg/day

Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: None observed

Species Effect Level Dose Experiment Length
Rat NOEL 15 ppm 2 years

References
1984 Klimisch H.J. and W. Reininghaus. 1984. Carcinogenicity of Acrylates: long-term inhalation studies on Methyl Acrylate (MA) and n-Butyl Acrylate (BA) in rats. Toxicologist. 4(1): 53.
1987 U.S. EPA. 1987. Health and environmental effects profile for Methyl Acrylate. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
Subchronic [RfD] Comments: Based on route to route extrapolation.
Chronic [RfD] Comments: Based on route to route extrapolation.
General Comments: No pharmacokinetic data were provided to justify route to route extrapolation for the oral [RfD] values.


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