Health Effects Assessment Summary (HEAST) for
Methyl Acetate
CAS: 000079-20-9
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Chronic [RfD]: (see comment) |
1E+0 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Subchronic [RfD]: | 1E+1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: gavage | |||
| Target Organ / Critical Effect: | Liver / Increased alkaline phosphatase | |||
| Liver / Increased SGPT | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOEL | 1156 mg/kg/day | 90 days | |
| References | ||||
| 1986 | Toxicity Research Laboratory. 1986. Rat oral subchronic toxicity study with Methanol. Sponsored by Office of Solid Waste, U.S. EPA, Washington, DC | |||
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for Methyl Acetate. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| Chronic [RfD] Comments: | Calculated from data obtained with methanol by multiplying by the molecular weight ratio (74.08/32.04). | |||
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