Health Effects Assessment Summary (HEAST) for
Methoxyethanol Acetate, 2-
CAS: 000110-49-6
| Summary of HEAST Information on-Line | ||||||
| Alternative Methods | ||||||
|
| Chronic [RfD]: (see comment) |
2E-3 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Subchronic [RfD]: (see comment) |
2E-2 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Testis / Degeneration | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rabbit | NOAEL | 10 ppm | 13 weeks | |
| References | ||||
| 1982 | Miller R.R., L.L. Calhoun and B.L. Yano. 1982. Ethylene Glycol Monomethyl ether: 13-week vapor inhalation study in male rabbits. Report prepared for the Chemical Manufacturers Association, March 25, 1982. | |||
| 1987 | U.S. EPA. 1987. Health and environmental effects profile for 2-Methoxyethanol acetate. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| Subchronic [RfD] Comments: | Based on route to route extrapolation using an absorption factor of 0.5. Calculated from data obtained with methoxyethanol converted by multiplying by the molecular weight ratio (118.13/76.09). | |||
| Chronic [RfD] Comments: | Based on route to route extrapolation using an absorption factor of 0.5. Calculated from data obtained with Methoxyethanol converted by multiplying by the molecular weight ratio (118.13/76.09). | |||
| General Comments: | No pharmacokinetic data were provided to justify route to route extrapolation for the oral [RfD] values. | |||
[ Risk Assessment Home ]
[ EPA Home |
OSWER Home | Superfund Home ]
[ Search EPA
| Search Superfund
| Whats New |
Contact Us ]
URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov