Health Effects Assessment Summary (HEAST) for
Methacrylonitrile
CAS: 000126-98-7
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
| ||||||
| Alternative Methods | ||||||
|
| Subchronic [RfD]: (see comment) |
1E-3 mg/kg/day | |||
| Uncertainty Factor: | 300 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Liver / Increased SGOT | |||
| Liver / Increased SGPT | ||||
| Central nervous system / Loss of hindlimb motor control | ||||
| Brain / Lesions | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Dog | NOAEL | 3.2 ppm | 90 days | |
| References | ||||
| 1968 | Pozzani U.C., C.R. Kinkead, and J.M. King. 1968. The mammalian toxicity of Methacrylonitrile. Am Ind Hyg Assoc J. 29(3): 202-210. | |||
| 1987 | U.S. EPA. 1987. Health and environmental effects document for selected Nitriles. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Solid Waste and Emergency Response. | |||
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | Based on route to route extrapolation. | |||
| Chronic [RfC]: (see comment) |
7E-4 mg/kg/day | |||
| Uncertainty Factor: | 3000 | |||
| Subchronic [RfC]: (see comment) |
7E-3 mg/cu m | |||
| Uncertainty Factor: | 300 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Liver / Increased SGOT | |||
| Liver / Increased SGPT | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Dog | NOEL | 3.2 ppm | 90 days | |
| References | ||||
| 1968 | Pozzani, U.C., C.R. Kinkead and J.M. King. 1968. The mammalian toxicity of Methacrylonitrile. Am Ind Hyg Assoc J. 29(3): 202-210. | |||
| 1987 | U.S. EPA. 1987. Health and environmental effects document for selected Nitriles, prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| Subchronic [RfC] Comments: | 2E-3 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). These values differ from those in the 1987 HEED. | |||
| Chronic [RfC] Comments: | 2E-4 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). These values differ from those in the 1987 HEED. | |||
| General Comments: | The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group. | |||
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