Health Effects Assessment Summary (HEAST) for
Merphos Oxide
CAS: 000078-48-8
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
3E-4 mg/kg/day | |||
| Uncertainty Factor: | 300 | |||
| Route: | Oral: capsule | |||
| Target Organ / Critical Effect: | Nervous system / Ataxia | |||
| Nervous system / Delayed neurotoxicity | ||||
| Whole body / Decreased weight | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Hen | NOEL | 0.1 mg/kg/day | 3 months | |
| References | ||||
| 1979 | Abou-Donia M.B., D.G. Graham, K.M. Abdo, and A.A. Komeil. 1979. Delayed neurotoxic, late acute and cholinergic effects of s,s,s-Tributylphosphorotrithioate (DEF): Subchronic (90 days) administration in hens. Toxicology. 14: 229-243. | |||
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Merphos Oxide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC | |||
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was modified to estimate the subchronic oral [RfD]. | |||
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