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Health Effects Assessment Summary (HEAST) for

Merphos

CAS: 000150-50-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 3E-4 mg/kg/day

Uncertainty Factor: 300

Route: Oral: capsule

Target Organ / Critical Effect: Nervous system / Ataxia
Nervous system / Delayed neurotoxicity
Whole body / Decreased weight

Species Effect Level Dose Experiment Length
Hen NOEL 0.1 mg/kg/day 3 months

References
1980 Abou-Donia M.B., D.G. Graham, P.R. Timmons, and B.L. Reichert. 1980. Late acute, delayed neurotoxic and cholinergic effects of s,s,s-Tributylphosphorotrithioite (Merphos) in hens. Toxicol Appl Pharmacol. 53: 439-457.
1984 U.S. EPA. 1984. Health and environmental effects profile for Merphos. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC
1987 U.S. EPA. 1987. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was modified to estimate the subchronic oral [RfD].


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