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Health Effects Assessment Summary (HEAST) for

Mephosfolan

CAS: 000950-10-7

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: 9E-5 mg/kg/day
Uncertainty Factor: 1000

Subchronic [RfD]: 9E-4 mg/kg/day
Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: Liver / Altered weight
Kidney / Altered weight
Blood / Decreased cholinesterase activity
Erythrocytes / Decreased cholinesterase activity
Brain / Decreased cholinesterase activity

Species Effect Level Dose Experiment Length
Rat NOEL 0.09 mg/kg/day 17 weeks

References
1984 U.S. EPA. 1984. Health and environmental effects profile for Mephosfolan. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC


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