Health Effects Assessment Summary (HEAST) for
Manganese
CAS: 007439-96-5
| Summary of HEAST Information on-Line | ||||||||
| Subchronic and Chronic Toxicity | ||||||||
|
| Subchronic [RfD]: (see comment) |
1.4E-1 mg/kg/day | |||
| Uncertainty Factor: | 1 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Central nervous system / Effects | |||
| Species | Effect Level | Dose | Experiment Length | |
| Human | NOAEL | 0.14 mg/kg/day | Chronic | |
| References | ||||
| 1973 | WHO (World Health Organization). 1973. Trace elements in human nutrition: Manganese. Report of a WHO expert committee. Technical report service, 532, WHO, Geneva, Switzerland. Pp 34-36. | |||
| 1966 | Schroeder H.A., J.J. Balassa, I.H. Tipton. 1966. Essential trace metals in man: Manganese, a study in homeostasis. J Chron Dis. 19: 545-571. | |||
| 1989 | NRC (National Research Council). 1989. Recommended dietary allowances, 10th ed. Food and Nutrition Board, National Research Council, National Academy Press, Washington, DC Pp 230-235. | |||
| 1992 | U.S. EPA. 1992. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral food RfD was adopted as the subchronic oral food [RfD]. See IRIS for specific dietary information. | |||
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