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Health Effects Assessment Summary (HEAST) for
Malononitrile
CAS: 000109-77-3
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Chronic [RfD]: |
2E-5 mg/kg/day |
| Uncertainty Factor: |
10000 |
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| Subchronic [RfD]: |
2E-4 mg/kg/day |
| Uncertainty Factor: |
1000 |
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| Route: |
Oral: gavage |
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| Target Organ / Critical Effect: |
Liver / Effects |
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Spleen / Effects |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
LOAEL |
0.21 mg/kg/day |
120 days |
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| References |
| 1972 | Panov I., M. Zlateva and G. Antov. 1972. Toxicological characteristics of Dicyanomethane. Chronic effects in white rats. Khig. Zdraveopazvane. 15(6): 553-562. |
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for Malononitrile. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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