Health Effects Assessment Summary (HEAST) for
Maleic Anhydride
CAS: 000108-31-6
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
1E-1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Kidney / Lesions | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 10 mg/kg/day | 2 years | |
| References | ||||
| 1982 | Jessup D.C., D. Aldridge, J.L. Schardein and M. Blair. 1982. Three-generation reproduction study in rats (modified to a 2-generation study). Maleic Anhydride ir-79-358. International Research and Development Corp. for Monsanto Co., St. Louis, MO, Unpublished 8D submission. Microfiche No. OTS 0206655. Document ID 878214777 | |||
| 1983 | Preache M. 1983. Chronic dietary administration of Maleic Anhydride. Vol. 1: Narrative. FYI-OTS submission 1283-0277. Prepared by ITT Research Institute for Chemical Industry Institute of Technology, Research Triangle Park, NC. | |||
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for Maleic Anhydride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| 1988 | U.S. EPA. 1988. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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