Health Effects Assessment Summary (HEAST) for
Malathion
CAS: 000121-75-5
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
2E-2 mg/kg/day | |||
| Uncertainty Factor: | 10 | |||
| Route: | Oral: capsule | |||
| Target Organ / Critical Effect: | Blood / Hematological effects | |||
| Species | Effect Level | Dose | Experiment Length | |
| Human | NOEL | 0.23 mg/kg/day | 47 days | |
| References | ||||
| 1962 | Moeller H.C. and J.A. Rider. 1962. Plasma and red blood cell-cholinesterase activity as indications of the threshold of incipient toxicity of Ethyl-p-nitrophenol Thionebenzenephosphorate (EPN) and Malathion in human beings. Toxicol Appl Pharmacol. 4: 123-130. | |||
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Malathion. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC | |||
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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