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Health Effects Assessment Summary (HEAST) for

Isophorone

CAS: 000078-59-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Carcinogenicity
Oral [Slope Factor]:IRIS
Oral [Unit Risk]:IRIS
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 2E+0 mg/kg/day
Uncertainty Factor: 100

Route: Oral: capsule

Target Organ / Critical Effect: Kidney / Lesions

Species Effect Level Dose Experiment Length
Dog NOEL 150 mg/kg/day 90 days

References
1972 Nor-Am Agricultural Products, Inc. 1972. MRID No. 00123976. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1986 NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of Isophorone (CAS No. 78-59-1) in F344/N rats and B6C3F1 mice (gavage studies). NTP Tech Report SER No. 291, NIH Publ No. 86-2547.
1993 U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for Isophorone. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC
1989 U.S. EPA. 1989. RfD/RfC Work Group.


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