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Health Effects Assessment Summary (HEAST) for

Hydrogen Sulfide

CAS: 007783-06-4


Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line






Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 3E-2 mg/kg/day
Uncertainty Factor: 100

Route: Oral: food

Target Organ / Critical Effect: Gastrointestinal system / Disturbance

Species Effect Level Dose Experiment Length
Pig NOAEL 3.1 mg/kg/day 105 days

References
1964 Watterau H., W. Oeckert and U.G. Knape. 1964. Tests for the application of dried green fodder with high H2S content (experiments with poultry and fattened pigs). Lettin Feeds Testing Center and Feeding Hall. Feeds Science. Fetterung. 5: 383-393.
1985 U.S. EPA. 1985. RfD/RfC Work Group.





Subchronic [RfC]: 1E-2 mg/cu m
Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Nasal mucosa / Inflammation

Species Effect Level Dose Experiment Length
Mouse NOAEL 42 mg/cu m 13 weeks

References
1983 CIIT. 1983. 90 day vapor inhalation toxicity study of Hydrogen Sulfide in B6C3F1 mice. EPA OTS public files. Fiche No. 0000255-0. Document No. FYI-OTS-0883-0255.
1990 U.S. EPA. 1990. Health and environmental effects document for Hydrogen Sulfide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Solid Waste and Emergency Response, Washington, DC
1995 U.S. EPA. 1995. RfD/RfC Work Group.



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