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Health Effects Assessment Summary (HEAST) for

Hexane, n-

CAS: 000110-54-3

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: 6E-2 mg/kg/day
Uncertainty Factor: 10000

Subchronic [RfD]: 6E-1 mg/kg/day
Uncertainty Factor: 1000

Route: Oral

Target Organ / Critical Effect: Nervous system / Neuropathy
Testis / Atrophy

Species Effect Level Dose
Rat LOAEL 570 mg/kg/day

References
1980 Krasavage W.J., J.L. O'donoghue, G.D. Divincenzo and Terhaar. 1980. Relative neurotoxicity of Methyl-n-butyl Ketone, n-Hexane and their metabolites. Toxicol Appl Pharmacol. 52(3): 433-441.
1989 U.S. EPA. 1989. Health and environmental effects document for n-Hexane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC




Subchronic [RfC]:
(see comment)		 2E-1 mg/cu m

Uncertainty Factor: 300

Route: Inhalation: intermittent

Target Organ / Critical Effect: Nervous system / Neurotoxicity

Species Effect Level Dose
Human LOAEL 73 mg/cu m

References
1980 Sanagi S., Y. Seki, K. Sugimoto and M. Hirata. 1980. Peripheral nervous system functions of workers exposed to n-Hexane at a low level. Int Arch Occup Environ Health. 47: 69-79.
Subchronic [RfC] Comments: The chronic inhalation RfC was adopted as the subchronic inhalation [RfC].


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