HEAST Summary

Health Effects Assessment Summary (HEAST) for
Hexachloroethane

CAS: 000067-72-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Carcinogenicity

Oral [Slope Factor]: IRIS

Inhalation [Slope Factor]: on-Line

Oral [Unit Risk]: IRIS

Inhalation [Unit Risk]: IRIS

EPA Group: IRIS

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:	1E-2 mg/kg/day
Uncertainty Factor:	100

Route:	Oral: diet

Target Organ / Critical Effect:	Kidney / Degeneration

Species	Effect Level	Dose	Experiment Length
Rat	NOAEL	1 mg/kg/day	16 weeks

References
1985	Gorzinski, S.J., R.J. Nolan, S.B. McCollister, et al. 1985. Subchronic oral toxicity, tissue distribution and clearance of Hexachloroethane in the rat. Drug Chem Toxicol. 8(3): 155-169.
1989	U.S. EPA. 1989. Health and environmental effects document for Hexachloroethane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Solid Waste and Emergency Response, Washington, DC
1987	U.S. EPA. 1987. RfD/RfC Work Group.


Carcinogenicity

Inhalation [Slope Factor]: (see comment)	1.4E-2 (mg/kg/day)^-1


Route:	Oral: gavage

Target Organ / Cancer:	Liver / Carcinoma

Species	Experiment Length	EPA Group
Mouse	78 weeks	IRIS

References
1978	NCI (National Cancer Institute). 1978. Bioassay of Hexachloroethane for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 68, DHEW No. (NIH) 78-1318.
1989	U.S. EPA. 1989. Health and environmental effects document for Hexachloroethane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1980	U.S. EPA. 1980. Ambient Water Quality Criteria document for chlorinated Ethanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulations and Standards, Washington, DC.
1987	U.S. EPA. 1987. Health effects assessment for Hexachloroethane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1986	U.S. EPA. 1986. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

Inhalation Slope Comment:	Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST.

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