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Health Effects Assessment Summary (HEAST) for
Hexachlorocyclopentadiene
CAS: 000077-47-4
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Subchronic [RfD]: |
7E-2 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral |
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| Target Organ / Critical Effect: |
Forestomach / Lesions |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
7.1 mg/kg/day |
13 weeks |
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| References |
| 1984 | Abdo K.M., C.A. Montgomery, W.M. Kluwe et al. 1984. Toxicity of Hexachlorocyclopentadiene: Subchronic (13-week) administration by gavage to F344 rats and B6C3F1 mice. J Appl Toxicol. 4: 75-81. |
| 1991 | U.S. EPA. 1991. Drinking water criteria document for Hexachlorocyclopentane. Prepared by the Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Cincinnati, OH for the Office of Water, Washington, DC |
| 1985 | U.S. EPA. 1985. RfD/RfC Work Group. |
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| Chronic [RfC]: |
7E-5 mg/cu m |
| Uncertainty Factor: |
1000 |
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| Subchronic [RfC]: |
7E-4 mg/cu m |
| Uncertainty Factor: |
100 |
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| Route: |
Inhalation: intermittent |
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| Target Organ / Critical Effect: |
Nasal cavity / Squamous metaplasia |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
0.15 ppm |
13 weeks |
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| References |
| 1986 | Abdo K.M., C.A. Montgomery, J. Roycroft, H.A. Ragan, R.A. Renne, W.E. Giddins. 1986. Subchronic (13-week) inhalation toxicity of Hexachlorocyclopentadiene (HCCPD) in F344 rats and B6C3F1 mice. Abstract submitted to the society of toxicology from the 1986 meeting. |
| 1984 | Battelle Northwest Laboratories. 1984. Inhalation carcinogenesis bioassay study: Subchronic study report on Hexachlorocyclopentadiene in rats. Submitted to the National Toxicology Program. |
| 1991 | U.S. EPA. 1991. Drinking water criteria document for Hexachlorocyclopentadiene. Prepared by the Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC |
| 1988 | U.S. EPA. 1988. Health and environmental effects document for Hexachlorocyclopentadiene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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