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Health Effects Assessment Summary (HEAST) for

Hexachlorocyclohexane-Technical

CAS: 000608-73-1


Summary of HEAST Information on-Line

Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line






Carcinogenicity

Inhalation [Slope Factor]:
(see comment)
1.8E+0 (mg/kg/day)-1


Route: Oral: diet

Target Organ / Cancer: Liver / Tumors

Species Experiment Length EPA Group
Mouse 6-20 months IRIS

References
1983 Munir K.M., C.S. Soman and V. Sumati. 1983. Hexachlorocyclohexane-induced tumorigenicity in mice under different experimental conditions. Tumorigenicity. 69: 383-386.
1987 U.S. EPA. 1987. Health and environmental effects profile for Hexachlorocyclohexanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1986 U.S. EPA. 1986. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

Inhalation Slope Comment: Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST.



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