HEAST Summary

Health Effects Assessment Summary (HEAST) for
Hexachlorocyclohexane, Gamma-

CAS: 000058-89-9

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Carcinogenicity

Oral [Slope Factor]: on-Line

Oral [Unit Risk]: on-Line

EPA Group: on-Line

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:	3E-3 mg/kg/day
Uncertainty Factor:	100

Route:	Oral: diet

Target Organ / Critical Effect:	Liver / Toxicity
	Kidney / Toxicity

Species	Effect Level	Dose	Experiment Length
Rat	NOAEL	0.33 mg/kg/day	12 weeks

References
1983	Zoecon Corporation. 1983. MRID No. 00128356. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1986	U.S. EPA. 1986. RfD/RfC Work Group.


Carcinogenicity

Oral [Slope Factor]: (see comment)	1.3E+0 (mg/kg/day)^-1


Oral [Unit Risk]:	3.7E-5 (µg/L)^-1

Route:	Oral: diet

Target Organ / Cancer:	Liver / Tumors

Species	Experiment Length	EPA Group
Mouse	110 weeks	B2-C

References
1973	Thorpe, E. and A.I.T. Walker. 1973. The toxicology of Dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with Dieldrin, DDT, Phenobarbitone, beta-BHC and gamma-BHC. Food Cosmet Toxicol. 11: 433-442.
1987	U.S. EPA. 1987. Health and environmental effects profile for Hexachlorocyclohexanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington DC.
1984	U.S. EPA. 1984. Health effects assessment for Lindane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Emergency and Remedial Response, Washington, DC.

Oral Slope Comment:	Under review, number subject to change.

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