Health Effects Assessment Summary (HEAST) for
Hexachlorobutadiene
CAS: 000087-68-3
| Summary of HEAST Information on-Line | ||||||||||||
| Subchronic and Chronic Toxicity | ||||||||||||
| ||||||||||||
| Carcinogenicity | ||||||||||||
|
| Chronic [RfD]: (see comment) |
2E-4 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Renal tubules / Regeneration | |||
| Species | Effect Level | Dose | Experiment Length | |
| Mouse | LOAEL | 0.5 mg/kg/day | 13 weeks | |
| References | ||||
| 1991 | NTP (National Toxicology Program). 1991. NTP report on the toxicity studies of Hexachloro-1,3-butadiene in B6C3F1 mice (feed studies). | |||
| 1989 | Yang et al. 1989. Hexachlorobutadiene - Subchronic toxicology studies of Hexachloro-1,3-Butadiene (HCBD) in B6C3F1 mice by dietary incorporation. J Environ Pathol Toxicol Oncol. P. 323-332. | |||
| 1977 | Kociba R.J., D.G. Keys, G.C. Jeresey, et al. 1977. Results of a 2-year chronic toxicity study with Hexachlorobutadiene in rats. Am Ind Hyg Assoc J. 38: 589-602. | |||
| 1993 | U.S. EPA. 1993. RfD/RfC Work Group. | |||
| Chronic [RfD] Comments: | Withdrawn from IRIS (05/01/93). Under review, current number subject to change. | |||
| Inhalation [Slope Factor]: (see comment) | 7.8E-2 (mg/kg/day)-1 | |||
| Route: | Oral: diet | |||
| Target Organ / Cancer: | Kidney / Tumors | |||
| Species | Experiment Length | EPA Group | ||
| Rat | 22-24 months | IRIS | ||
| References | ||||
| 1977 | Kociba, R.J., D.G. Keys, G.C. Jersey, et al. 1977. Results of a 2-year chronic toxicity study with Hexachlorobutadiene in rats. Am Ind Hyg Assoc J. 38: 589-602. | |||
| 1980 | U.S. EPA. 1980. Ambient Water Quality Criteria document for Hexachlorobutadiene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulations and Standards, Washington, DC. | |||
| 1984 | U.S. EPA. 1984. Health effects assessment for Hexachlorobutadiene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC. | |||
| 1986 | U.S. EPA. 1986. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group. | |||
| Inhalation Slope Comment: | Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST. | |||
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