Health Effects Assessment Summary (HEAST) for
Heptachlor Epoxide
CAS: 001024-57-3
| Summary of HEAST Information on-Line | ||||||||||||
| Subchronic and Chronic Toxicity | ||||||||||||
| ||||||||||||
| Carcinogenicity | ||||||||||||
|
| Subchronic [RfD]: (see comment) |
1.3E-5 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Liver / Increased relative weight | |||
| Species | Effect Level | Dose | Experiment Length | |
| Dog | LOAEL | 0.0125 mg/kg/day | 60 weeks | |
| References | ||||
| 1958 | Dow Chemical Co. 1958. MRID No. 00061912. Available from EPA. Write to FOI, EPA, Washington, DC 20460. | |||
| 1986 | U.S. EPA. 1986. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
| Inhalation [Slope Factor]: (see comment) | 9.1E+0 (mg/kg/day)-1 | |||
| Route: | Oral: diet | |||
| Target Organ / Cancer: | Liver / Carcinoma | |||
| Species | Experiment Length | EPA Group | ||
| Mouse | 18-24 months | IRIS | ||
| References | ||||
| 1965 | Davis K.J. 1965. Pathology report on mice fed Aldrin, Dieldrin, Heptachlor and Heptachlor Epoxide for two years. Internal FDA memorandum to Dr. A.J. Lehman. July 19. | |||
| 1973 | Velsicol Chemical Corporation. 1973. MRID No. 00062678. Available from EPA. Write to FOI, EPA, Washington, DC 20460. | |||
| 1987 | U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group. | |||
| Inhalation Slope Comment: | Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST. | |||
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