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Health Effects Assessment Summary (HEAST) for

Heptachlor

CAS: 000076-44-8

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 5E-4 mg/kg/day

Uncertainty Factor: 300

Route: Oral: diet

Target Organ / Critical Effect: Liver / Increased weight

Species Effect Level Dose Experiment Length
Rat NOEL 0.15 mg/kg/day 2 years

References
1955 Velsicol Chemical Corp. 1955. MRID No. 00062599. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1987 U.S. EPA. 1987. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		4.5E+0 (mg/kg/day)-1


Route: Oral: diet

Target Organ / Cancer: Liver / Carcinoma

Species EPA Group
Mouse IRIS

References
1965 Davis K. 1965. Pathology report on mice fed Aldrin, Dieldrin, Heptachlor, and Heptachlor Epoxide for two years. Internal FDA memorandum to Dr. A.J. Lehman, July 19.
1977 NCI (National Cancer Institute). 1977. Bioassay of Heptachlor for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 9, DHEW No. (NIH) 77-809.
1976 Epstein, S.S. 1976. Carcinogenicity of Heptachlor and Chlordane. Sci Total Environ. 6: 103-154.
1977 Reuber, M.D. 1977. Histopathology of carcinomas of the liver in mice ingesting Heptachlor or Heptachlor Epoxide. Exp Cell Biol. 45: 147-157.
1986 U.S. EPA. 1986. Carcinogenicity assessment of Chlordane and Heptachlor/Heptachlor Epoxide. Prepared by the Office of Health and Environmental Assessment, Carcinogen Assessment Group, Washington, DC.
1987 U.S. EPA. 1987. Health effects assessment for Heptachlor. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1987 U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST.


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