Health Effects Assessment Summary (HEAST) for
Furfural
CAS: 000098-01-1
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
| ||||||
| Alternative Methods | ||||||
|
| Chronic [RfC]: (see comment) |
5E-2 mg/cu m | |||
| Uncertainty Factor: | 1000 | |||
| Subchronic [RfC]: (see comment) |
5E-1 mg/cu m | |||
| Uncertainty Factor: | 100 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Nasal cavity / Olfactory degeneration | |||
| Species | Effect Level | Dose | Experiment Length | |
| Hamster | NOAEL | 20 ppm | 13 weeks | |
| References | ||||
| 1979 | Feron V.J., A. Kruysse and H.C. Dreef Vander Meulen. 1979. Repeated exposure to Furfural vapor: 13 week study in Syrian golden hamsters. Zentrase. Bakteviol Pavasiten Kd Infection SKV Hyg Abt 1 Orig Reihe B. 168(5-6): 442-451. | |||
| 1988 | U.S. EPA. 1988. Health and environmental effects document for Furfural. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| Subchronic [RfC] Comments: | 1E-1 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). | |||
| Chronic [RfC] Comments: | 1E-2 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). | |||
| General Comments: | The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group. | |||
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