HEAST Summary

Health Effects Assessment Summary (HEAST) for
Formaldehyde

CAS: 000050-00-0

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Carcinogenicity

Inhalation [Slope Factor]: on-Line

Inhalation [Unit Risk]: IRIS

EPA Group: IRIS

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:	2E-1 mg/kg/day
Uncertainty Factor:	100

Route:	Oral: water

Target Organ / Critical Effect:	Gastrointestinal tract / Lesions

Species	Effect Level	Dose	Experiment Length
Rat	NOAEL	15 mg/kg/day	2 years

References
1989	Til H.P., R.A. Woutersen, V.J. Feron et al. 1989. Two-year drinking water study of Formaldehyde in rats. Food Chem Toxicol. 27: 77-87.
1989	U.S. EPA. 1989. Draft drinking water health advisory for Formaldehyde. Office of Drinking Water, Washington, DC
1990	U.S. EPA. 1990. RfD/RfC Work Group.


Carcinogenicity

Inhalation [Slope Factor]: (see comment)	4.5E-2 (mg/kg/day)^-1


Route:	Inhalation

Target Organ / Cancer:	Nasal cavity / Tumors

Species	Experiment Length	EPA Group
Rat	24 months	IRIS

References
1983	Kerns et al., 1983. Carcinogenicity of Formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res. 43(9): 4382-4392.
1988	U.S. EPA. 1988. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
1985	U.S. EPA. 1985. Health and environmental effects profile for Formaldehyde. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

Inhalation Slope Comment:	See Appendix A-II: Dose Conversions on HEAST.

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