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Health Effects Assessment Summary (HEAST) for

Fluorine (Soluble Fluoride)

CAS: 007782-41-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 6E-2 mg/kg/day
Uncertainty Factor: 1

Route: Oral: drinking water

Target Organ / Critical Effect: Tooth / Fluorosis

Species Effect Level Dose
Human NOAEL 0.06 mg/kg/day

References
1950 Hodge H.C. 1950. The concentration of Fluorides in drinking water to give the point of minimum caries with maximum safety. J Am Dent Assoc. 40: 436.
1989 U.S. EPA. 1989. Health and environmental effects document for Fluoride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1986 U.S. EPA. 1986. RfD/RfC Work Group.


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