HEAST Summary

Health Effects Assessment Summary (HEAST) for
Ethylene Thiourea

CAS: 000096-45-7

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Notes/Comments: on-Line

Carcinogenicity

Oral [Slope Factor]: on-Line

Oral [Unit Risk]: on-Line

EPA Group: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: (see comment)	8E-5 mg/kg/day

Uncertainty Factor:	3000

Route:	Oral: diet

Target Organ / Critical Effect:	Thyroid / Hyperplasia

Species	Effect Level	Dose	Experiment Length
Rat	LOAEL	0.25 mg/kg/day	24 months

References
1975	Graham S.L., K.J. Davis, W.H. Hansen and C.H. Graham. 1975. Effects of prolonged Ethylene Thiourea ingestion on the thyroid of the rat. Food Cosmet Toxicol. 13: 493-499.
1991	U.S. EPA. 1991. RfD/RfC Work Group.

Subchronic [RfD] Comments:	The chronic oral RfD was adopted as the subchronic oral [RfD].


Carcinogenicity

Oral [Slope Factor]:	1.1E-1 (mg/kg/day)^-1

Oral [Unit Risk]:	3.4E-6 (µg/L)^-1

Route:	Oral: gavage

Target Organ / Cancer:	Liver / Adenoma/carcinoma, combined

Species	Experiment Length	EPA Group
Mouse	2 years	B2

References
1992	NTP (National Toxicology Program). 1992. NTP technical report on the perinatal toxicology and carcinogenesis studies of Ethylene thiourea (CAS No. 96-45-7) in F344/N rats and B6C3F1 mice. (feed studies). NTP TR 388. U.S. Dept of Health and Human Services. Public Health Service. National Institutes of Health.
1993	U.S. EPA. 1993. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

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