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Health Effects Assessment Summary (HEAST) for

Ethylene Oxide

CAS: 000075-21-8

Summary of HEAST Information on-Line

Carcinogenicity
Oral [Slope Factor]:on-Line
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
Inhalation [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Carcinogenicity
Oral [Slope Factor]:
(see comment)		 1.02E+0 (mg/kg/day)-1


Oral [Unit Risk]: 2.9E-5 (µg/L)-1

Route: Oral: gavage

Target Organ / Cancer: Stomach / Tumors

Species Experiment Length EPA Group
Rat Lifetime, twice weekly B1

References
1982 Dunkelberg H. 1982. Carcinogenicity of Ethylene Oxide and 1,2-Propylene Oxide upon intra-gastric administration to rats. Br J Cancer. 46: 924-933.
1984 U.S. EPA. 1984. Health and environmental effects profile for Oxirane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
Oral Slope Comment: Under review, number subject to change.




Inhalation [Slope Factor]: 3.5E-1 (mg/kg/day)-1

Inhalation [Unit Risk]:
(see comment)		 1E-4 (µg/m3)-1


Route: Inhalation: intermittent

Target Organ / Cancer: Blood / Leukemia
Brain / Glioma

Species Experiment Length EPA Group
Rat 2 years B1

References
1981 Snellings W.M., C.S. Weil and R.R. Moronpot. 1981. Final report, Ethylene Oxide, two year inhalation study. Submitted to the U.S. Environmental Protection Agency by Bushey Run Research Center, Pittsburgh PA.
1985 U.S. EPA. 1985. Health assessment document for Ethylene oxide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Research Triangle Park, NC. EPA 600/8-84-009F. NTIS PB86-102597.
Inhalation [Unit Risk] Comment: Under review, number subject to change.


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