|
|
|
|
Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
|
Chronic [RfD]: (see comment) |
9E-2 mg/kg/day |
|
Uncertainty Factor: |
100 |
|
Subchronic [RfD]: |
9E-2 mg/kg/day |
Uncertainty Factor: |
100 |
|
Route: |
Oral: drinking water |
|
Target Organ / Critical Effect: |
Kidney / Increased relative weight |
|
Species |
Effect Level |
Dose |
Experiment Length |
Rat |
NOEL |
7.5 mg/kg/day |
2 years |
|
References |
1964 | Borzelleca J.F., P.S. Larson, G.R. Hennigar, et al. 1964. Studies on the chronic oral toxicity of monomeric Ethyl Acrylate and Methyl Methacrylate. Toxicol Appl Pharmacol. 6: 29-36. |
1986 | U.S. EPA. 1986. Health and environmental effects profile for Ethyl Methacrylate. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
|
Chronic [RfD] Comments: |
Calculated from Methyl Methacrylate data by multiplying by the ratio of the molecular weights (114.5/100.13). |
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