Health Effects Assessment Summary (HEAST) for
Ethoxyethanol Acetate, 2-
CAS: 000111-15-9
| Summary of HEAST Information on-Line | ||||||
| Alternative Methods | ||||||
|
| Chronic [RfD]: (see comment) |
3E-1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Subchronic [RfD]: (see comment) |
3E-1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Fetus / Decreased ossification | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOEL | 30.1 mg/kg/day | Day 6-18 of gestation | |
| References | ||||
| 1984 | Union Carbide. 1984. A teratogenic evaluation of Cellosolve Acetate in Fisher 344 rats and New Zealand white rabbits following inhalation exposure. Bushy Run Research Center, Export, PA, October 1984. FYI-AX-1184-0360. | |||
| 1985 | U.S. EPA. 1985. Health and environmental effects profile for 2-Ethoxyethanol esters. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| Subchronic [RfD] Comments: | Based on route to route extrapolation. The subchronic oral [RfD] was based on a reproduction study with exposures during days 6-18 of gestation. | |||
| Chronic [RfD] Comments: | Based on route to route extrapolation. The chronic oral [RfD] was based on a reproduction study with exposures during days 6-18 of gestation. | |||
| General Comments: | No pharmacokinetic data were provided to justify route to route extrapolation for the oral [RfD] values. | |||
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