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Health Effects Assessment Summary (HEAST) for
Ethoxyethanol, 2-
CAS: 000110-80-5
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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Subchronic [RfD]:
(see comment) |
5E-1 mg/kg/day |
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| Uncertainty Factor: |
100 |
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| Route: |
Oral: gavage |
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| Target Organ / Critical Effect: |
Fetus / Skeletal malformations |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOEL |
50 ul/kg/day |
21 days |
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| References |
| 1971 | Stenger E.G., A. Lislott, D. Mueller et al. 1971. Toxicology of Ethylene Glycol Monoethyl Ether. Arzneim-Forsch. 21(6): 880-885. |
| 1984 | U.S. EPA. 1984. Health effects assessment for Glycol Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC EPA 540/1-86-052. |
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| Subchronic [RfD] Comments: |
Based on a reproduction study with exposures during days 1-21 of gestation. |
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| Chronic [RfD]: |
4E-1 mg/kg/day |
| Uncertainty Factor: |
1000 |
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| Route: |
Oral: gavage |
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| Target Organ / Critical Effect: |
Whole body / Decreased weight |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
LOAEL |
357 mg/kg/day |
103 weeks |
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| References |
| 1984 | Melnick R.L. 1984. Toxicities of Ethylene Glycol and Ethylene Glycol Monoethyl Ether in Fischer 344/N rats and B6C3F1 mice. Environ Health Perspect. 57: 147-155. |
| 1985 | U.S. EPA. 1985. Health and environmental effects profile for 2-Ethoxy-ethanol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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| Subchronic [RfC]: |
2E+0 mg/cu m |
| Uncertainty Factor: |
30 |
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| Route: |
Inhalation: intermittent |
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| Target Organ / Critical Effect: |
Blood / Altered hematology |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rabbit |
NOAEL |
380 mg/cu m |
13 weeks |
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| References |
| 1984 | Barbee S.J., J.B. Terrill, D.J. Desousa and C.C. Conaway. 1984. Subchronic inhalation toxicology of Ethylene Glycol Monoethyl Ether in the rat and rabbit. Environ Health Perspect. 57: 157-163. |
| 1984 | U.S. EPA. 1984. Health effects assessment for Glycol Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC EPA 540/1-86-052. |
| 1990 | U.S. EPA. 1990. RfD/RfC Work Group. |
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