HEAST Summary

Health Effects Assessment Summary (HEAST) for
Epichlorohydrin

CAS: 000106-89-8

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: on-Line

Subchronic [RfD]: on-Line

Chronic [RfC]: IRIS

Subchronic [RfC]: on-Line

Notes/Comments: on-Line

Carcinogenicity

Oral [Slope Factor]: IRIS

Inhalation [Slope Factor]: on-Line

Oral [Unit Risk]: IRIS

Inhalation [Unit Risk]: IRIS

EPA Group: IRIS

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: (see comment)	2E-3 mg/kg/day

Uncertainty Factor:	1000

Subchronic [RfD]: (see comment)	2E-3 mg/kg/day

Uncertainty Factor:	1000

Route:	Inhalation: intermittent

Target Organ / Critical Effect:	Kidney / Lesions

Species	Effect Level	Dose	Experiment Length
Rat	LOAEL	37.8 mg/cu m	136 weeks

References
1980	Laskin S., A.R. Sellakumar, M. Kuschner, et al. 1980. Inhalation carcinogenicity of Epichlorohydrin in non-inbred Sprague-Dawley rats. J Natl Cancer Inst. 65(4): 751-757.
1984	U.S. EPA. 1984. Health assessment document for Epichlorohydrin. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Research Triangle Park, NC. EPA 600/8-83-032F. NTIS PB85-132363.
1991	U.S. EPA. 1991. RfD/RfC Work Group.

Subchronic [RfD] Comments:	Based on route-to-route extrapolation. The chronic oral [RfD] was adopted as the subchronic oral [RfD].
Chronic [RfD] Comments:	Withdrawn from IRIS (04/01/92).


Subchronic [RfC]:	1E-2 mg/cu m
Uncertainty Factor:	100

Route:	Inhalation: intermittent

Target Organ / Critical Effect:	Nasal epithelium / Lesions

Species	Effect Level	Dose	Experiment Length
Rat	NOAEL	19 mg/cu m	90 days

References
1979	Quast J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna.1979. Epichlorohydrin - subchronic studies. I. A 90-day inhalation study in laboratory rodents. (Fischer 344 rats, Sprague-Dawley rats and B6C3F1 mice). Dow Chemical USA, Midland, MI.
1991	U.S. EPA. 1991. RfD/RfC Work Group.


Carcinogenicity

Inhalation [Slope Factor]: (see comment)	4.2E-3 (mg/kg/day)^-1


Route:	Inhalation: intermittent

Target Organ / Cancer:	Nasal cavity / Tumors

Species	Experiment Length	EPA Group
Rat	30 days, observed for lifetime	IRIS

References
1980	Laskin S., A.R. Sellakumar, M. Kuschner, et al. 1980. Inhalation carcinogenicity of Epichlorohydrin in non-inbred Sprague-Dawley rats. J Natl Cancer Inst. 65(4): 751-757.
1984	U.S. EPA. 1984. Health assessment document for Epichlorohydrin. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Research Triangle Park, NC. EPA 600/8-83-032f. NTIS PB85-132363.
1985	U.S. EPA. 1985. Health and environmental effects profile for Epichlorohydrin. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1986	U.S. EPA. 1986. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

Inhalation Slope Comment:	See Appendix A-II, Dose Conversions on HEAST.

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