Health Effects Assessment Summary (HEAST) for
Diphenylamine, n,n-
CAS: 000122-39-4
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
2.5E-2 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Whole body / Decreased weight gain | |||
| Liver / Increased weight | ||||
| Kidney / Increased weight | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Dog | NOEL | 2.5 mg/kg/day | 2 years | |
| References | ||||
| 1967 | Thomas J.O., W.E. Ribelin, J.R. Woodward and F. Deeds. 1967. The chronic toxicity of Diphenylamine for dogs. Toxicol Appl Pharmacol. 11: 184-194. | |||
| 1985 | U.S. EPA. 1985. Health and environmental effects profile for n,n-Diphenylamine. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| 1986 | U.S. EPA. 1986. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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