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Health Effects Assessment Summary (HEAST) for

Dinitrotoluene, 2,6-

CAS: 000606-20-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Oral [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)		 1E-3 mg/kg/day

Uncertainty Factor: 3000

Subchronic [RfD]: 1E-2 mg/kg/day
Uncertainty Factor: 300

Route: Oral: diet

Target Organ / Critical Effect: Whole body / Mortality
Central nervous system / Neurotoxicity
Blood / Heinz bodies
Blood / Methemoglobinemia
Bile duct / Hyperplasia
Kidney / Histopathology

Species Effect Level Dose Experiment Length
Dog NOAEL 4 mg/kg/day 13 weeks

References
1976 Lee C.C. et al. 1976. Mammalian toxicity of munitions compounds. Phase II: Effects of multiple doses. Part III: 2,6-Ditinrotoluene. US Army Medical Research and Development Command, Fort Detrick, MD.
1986 U.S. EPA. 1986. Health and environmental effects profile for Dinitrotoluene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1991 U.S. EPA. 1991. RfD/RfC Work Group.
Chronic [RfD] Comments: Under review, current number subject to change.


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