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Health Effects Assessment Summary (HEAST) for

Dinitrotoluene, 2,4-

CAS: 000121-14-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Oral [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 2E-3 mg/kg/day

Uncertainty Factor: 100

Route: Oral: gelatin capsule

Target Organ / Critical Effect: Central nervous system / Neurotoxicity
Erythrocytes / Heinz bodies
Biliary tract / Hyperplasia

Species Effect Level Dose Experiment Length
Dog NOAEL 0.2 mg/kg/day Up to 2 years

References
1985 Ellis H.V., C.B. Hong, C.C. Lee, et al. 1985. Subchronic and chronic toxicity studies of 2,4-Dinitrotoluene. Part I. Beagle dogs. J Am College Toxicol. 4(4): 233-242.
1986 U.S. EPA. 1986. Health and environmental effects profile for Dinitrotoluene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1991 U.S. EPA. 1991. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD is adopted as the subchronic oral [RfD].


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