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Health Effects Assessment Summary (HEAST) for

Dinitrobenzene, 1,4-

CAS: 000100-25-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)		 4E-4 mg/kg/day

Uncertainty Factor: 1000

Subchronic [RfD]:
(see comment)		 4E-3 mg/kg/day

Uncertainty Factor: 100

Route: Oral: drinking water

Target Organ / Critical Effect: Spleen / Increased weight

Species Effect Level Dose Experiment Length
Rat NOAEL 0.4 mg/kg/day 16 weeks

References
1981 Cody T.E., S. Witherup, L. Hastings, K. Stemmer and R.T. Christian. 1981. 1,3-Dinitrobenzene: Toxic effect in vivo and in vitro. J Toxicol Environ Health. 7(5): 829-847.
1985 U.S. EPA. 1985. Health and environmental effects profile for Dinitrobenzenes (o-, m-, p-). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
Subchronic [RfD] Comments: Derived by analogy to 1,3-dinitrobenzene.
Chronic [RfD] Comments: Derived by analogy to 1,3-Dinitrobenzene.


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